Key Components of Reconstitution Solutions:
- Sterile Water for Injection (SWFI): Sterile water for injection is purified water that meets the requirements of the United States Pharmacopeia (USP) for use in pharmaceutical preparations. It is free from additives, preservatives, and microbial contaminants, making it suitable for reconstituting many powdered medications.
- Bacteriostatic Water for Injection (BWFI): Bacteriostatic water for injection is sterile water that contains a small amount of a bacteriostatic agent, such as benzyl alcohol, to inhibit the growth of bacteria in the reconstituted solution. This allows for multiple withdrawals from the same vial over a period of time without increasing the risk of contamination.
- Normal Saline (0.9% Sodium Chloride): Normal saline is a solution of sodium chloride (salt) dissolved in sterile water to create a concentration of 0.9%. It is isotonic with bodily fluids and is commonly used as a reconstitution solution for medications that require a saline base.
- Sterile Diluents: Some medications may require specific sterile diluents or solvents for reconstitution, depending on their chemical properties and stability. These diluents are formulated to ensure proper solubility and stability of the medication when mixed.
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